Updates on immunologic correlates of vaccine-induced protection
SA Plotkin - Vaccine, 2020 - Elsevier
SA Plotkin
Vaccine, 2020•ElsevierCorrelates of protection (CoPs) are increasingly important in the development and licensure
of vaccines. Although the study of CoPs was initially directed at identifying a single immune
function that could explain vaccine efficacy, it has become increasingly clear that there are
often multiple functions responsible for efficacy. This review is meant to supplement prior
articles on the subject, illustrating both simple and complex CoPs.
of vaccines. Although the study of CoPs was initially directed at identifying a single immune
function that could explain vaccine efficacy, it has become increasingly clear that there are
often multiple functions responsible for efficacy. This review is meant to supplement prior
articles on the subject, illustrating both simple and complex CoPs.
Abstract
Correlates of protection (CoPs) are increasingly important in the development and licensure of vaccines. Although the study of CoPs was initially directed at identifying a single immune function that could explain vaccine efficacy, it has become increasingly clear that there are often multiple functions responsible for efficacy. This review is meant to supplement prior articles on the subject, illustrating both simple and complex CoPs.
Elsevier