[HTML][HTML] Maturation of thyroglobulin protein region I
In vertebrates, the thyroglobulin (Tg) gene product must be exported to the lumen of thyroid
follicles for thyroid hormone synthesis. In toto, Tg is composed of multiple type-1 repeats
connected by linker and hinge (altogether considered as" region I," nearly 1,200 residues);
regions II-III (∼ 720 residues); and cholinesterase-like (ChEL) domain (∼ 570 residues).
Regions II-III and ChEL rapidly acquire competence for secretion, yet regions I-II-III require
20 min to become a partially mature disulfide isomer; stabilization of a fully oxidized form …
follicles for thyroid hormone synthesis. In toto, Tg is composed of multiple type-1 repeats
connected by linker and hinge (altogether considered as" region I," nearly 1,200 residues);
regions II-III (∼ 720 residues); and cholinesterase-like (ChEL) domain (∼ 570 residues).
Regions II-III and ChEL rapidly acquire competence for secretion, yet regions I-II-III require
20 min to become a partially mature disulfide isomer; stabilization of a fully oxidized form …