[HTML][HTML] Protective and toxic neuroinflammation in amyotrophic lateral sclerosis
KG Hooten, DR Beers, W Zhao, SH Appel - Neurotherapeutics, 2015 - Elsevier
Amyotrophic lateral sclerosis (ALS) is a clinically heterogeneous disorder characterized by
loss of motor neurons, resulting in paralysis and death. Multiple mechanisms of motor
neuron injury have been implicated based upon the more than 20 different genetic causes of
familial ALS. These inherited mutations compromise diverse motor neuron pathways leading
to cell-autonomous injury. In the ALS transgenic mouse models, however, motor neurons do
not die alone. Cell death is noncell-autonomous dependent upon a well orchestrated …
loss of motor neurons, resulting in paralysis and death. Multiple mechanisms of motor
neuron injury have been implicated based upon the more than 20 different genetic causes of
familial ALS. These inherited mutations compromise diverse motor neuron pathways leading
to cell-autonomous injury. In the ALS transgenic mouse models, however, motor neurons do
not die alone. Cell death is noncell-autonomous dependent upon a well orchestrated …