[HTML][HTML] Identification and functional analysis of a novel cyclin e/cdk2 substrate ankrd17
M Deng, F Li, BA Ballif, S Li, X Chen, L Guo… - Journal of biological …, 2009 - ASBMB
Cyclin E/Cdk2 is a key regulator in G 1-S transition. We have identified a novel cyclin E/Cdk2
substrate called Ankrd17 (ankyrin repeat protein 17) using the TAP tag purification
technique. Ankrd17 protein contains two clusters of a total 25 ankyrin repeats at its N
terminus, one NES (nuclear exporting signal) and one NLS (nuclear localization signal) in
the middle, and one RXL motif at its C terminus. Ankrd17 is expressed in various tissues and
associates with cyclin E/Cdk2 in an RXL-dependent manner. It can be phosphorylated by …
substrate called Ankrd17 (ankyrin repeat protein 17) using the TAP tag purification
technique. Ankrd17 protein contains two clusters of a total 25 ankyrin repeats at its N
terminus, one NES (nuclear exporting signal) and one NLS (nuclear localization signal) in
the middle, and one RXL motif at its C terminus. Ankrd17 is expressed in various tissues and
associates with cyclin E/Cdk2 in an RXL-dependent manner. It can be phosphorylated by …