T lymphocytes and vascular inflammation contribute to stress-dependent hypertension
BACKGROUND: Psychological stress is a significant risk factor for hypertension and also
directly affects the immune system. We have previously reported that T lymphocytes are
essential for development of hypertension and that the central nervous system contributes to
peripheral T-lymphocyte activation and vascular inflammation in this disease; however, the
role of T-cell activation in stress-related hypertension remains unclear. METHODS: Wild-type
and T-cell-deficient (RAG-1−/−) mice were subjected to daily episodes of stress and blood …
directly affects the immune system. We have previously reported that T lymphocytes are
essential for development of hypertension and that the central nervous system contributes to
peripheral T-lymphocyte activation and vascular inflammation in this disease; however, the
role of T-cell activation in stress-related hypertension remains unclear. METHODS: Wild-type
and T-cell-deficient (RAG-1−/−) mice were subjected to daily episodes of stress and blood …