[PDF][PDF] What ignites UCP1?
B Cannon, J Nedergaard - Cell metabolism, 2017 - cell.com
B Cannon, J Nedergaard
Cell metabolism, 2017•cell.comWe thought we knew how the heat-producing uncoupling protein 1 in brown adipose tissue
was activated: by fatty acids released upon lipid droplet breakdown in the brown adipocytes.
However, two studies in this issue (Schreiber et al., 2017; Shin et al., 2017) imply that this
classical model may not be valid: heat can be produced in brown fat without intracellular
lipolysis.
was activated: by fatty acids released upon lipid droplet breakdown in the brown adipocytes.
However, two studies in this issue (Schreiber et al., 2017; Shin et al., 2017) imply that this
classical model may not be valid: heat can be produced in brown fat without intracellular
lipolysis.
We thought we knew how the heat-producing uncoupling protein 1 in brown adipose tissue was activated: by fatty acids released upon lipid droplet breakdown in the brown adipocytes. However, two studies in this issue (Schreiber et al., 2017; Shin et al., 2017) imply that this classical model may not be valid: heat can be produced in brown fat without intracellular lipolysis.
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