[HTML][HTML] Lipid-tuned Zinc Transport Activity of Human ZnT8 Protein Correlates with Risk for Type-2 Diabetes*♦
Zinc is a critical element for insulin storage in the secretory granules of pancreatic beta cells.
The islet-specific zinc transporter ZnT8 mediates granular sequestration of zinc ions. A
genetic variant of human ZnT8 arising from a single nonsynonymous nucleotide change
contributes to increased susceptibility to type-2 diabetes (T2D), but it remains unclear how
the high risk variant (Arg-325), which is also a higher frequency (> 50%) allele, is correlated
with zinc transport activity. Here, we compared the activity of Arg-325 with that of a low risk …
The islet-specific zinc transporter ZnT8 mediates granular sequestration of zinc ions. A
genetic variant of human ZnT8 arising from a single nonsynonymous nucleotide change
contributes to increased susceptibility to type-2 diabetes (T2D), but it remains unclear how
the high risk variant (Arg-325), which is also a higher frequency (> 50%) allele, is correlated
with zinc transport activity. Here, we compared the activity of Arg-325 with that of a low risk …