[HTML][HTML] Interleukin-13 and its receptors in idiopathic interstitial pneumonia: clinical implications for lung function
SW Park, MH Ahn, HK Jang, AS Jang… - Journal of Korean …, 2009 - ncbi.nlm.nih.gov
Journal of Korean medical science, 2009•ncbi.nlm.nih.gov
Idiopathic interstitial pneumonia (IIP) is characterized by varying degrees of interstitial
fibrosis. IL-13 and IL-4 are strong inducers of tissue fibrosis, whereas IFN-γ has antifibrotic
potential. However, the roles of these substances in IIP remain unknown. IL-13, IL-4, and IFN-
γ were measured in the BAL fluid of 16 idiopathic pulmonary fibrosis (IPF) patients, 10
nonspecific interstitial pneumonia (NSIP) patients, and 8 normal controls. The expression of
IL-13 and IL-13Rα1/α2 in lung tissues was analyzed using ELISA and …
fibrosis. IL-13 and IL-4 are strong inducers of tissue fibrosis, whereas IFN-γ has antifibrotic
potential. However, the roles of these substances in IIP remain unknown. IL-13, IL-4, and IFN-
γ were measured in the BAL fluid of 16 idiopathic pulmonary fibrosis (IPF) patients, 10
nonspecific interstitial pneumonia (NSIP) patients, and 8 normal controls. The expression of
IL-13 and IL-13Rα1/α2 in lung tissues was analyzed using ELISA and …
Abstract
Idiopathic interstitial pneumonia (IIP) is characterized by varying degrees of interstitial fibrosis. IL-13 and IL-4 are strong inducers of tissue fibrosis, whereas IFN-γ has antifibrotic potential. However, the roles of these substances in IIP remain unknown. IL-13, IL-4, and IFN-γ were measured in the BAL fluid of 16 idiopathic pulmonary fibrosis (IPF) patients, 10 nonspecific interstitial pneumonia (NSIP) patients, and 8 normal controls. The expression of IL-13 and IL-13Rα1/α2 in lung tissues was analyzed using ELISA and immunohistochemistry. IL-13 levels were significantly higher in IPF patients than the others (P< 0.05). IL-4 levels were higher in both IPF and NSIP patients than in normal controls (P< 0.05), and IFN-γ levels were lower in NSIP patients than in normal controls (P= 0.047). IL-13 levels correlated inversely with FVC%(r=-0.47, P= 0.043) and DLCO%(r=-0.58, P= 0.014) in IPF and NSIP patients. IL-13 was strongly expressed in the smooth muscle, bronchial epithelium, alveolar macrophages and endothelium of IPF patients. IL-13Rα1, rather than IL-13Rα2, was strongly expressed in the smooth muscle, bronchial epithelium, and endothelium of IPF patients. IL-13 and its receptors may contribute to the pathogenesis of fibrosis in IIP and appear to be related to the severity of the disease.
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