Alterations of endogenous sphingolipid metabolism in cardiometabolic diseases: Towards novel therapeutic approaches
M Le Barz, MM Boulet, C Calzada, D Cheillan… - Biochimie, 2020 - Elsevier
The increasing prevalence of obesity and metabolic diseases is a worldwide public health
concern, and the advent of new analytical technologies has made it possible to highlight the
involvement of some molecules, such as sphingolipids (SL), in their pathophysiology. SL are
constituents of cell membranes, lipoproteins and lipid droplets (LD), and are now considered
as bioactive molecules. Indeed, growing evidence suggests that SL, characterized by
diverse families and species, could represent one of the main regulators of lipid metabolism …
concern, and the advent of new analytical technologies has made it possible to highlight the
involvement of some molecules, such as sphingolipids (SL), in their pathophysiology. SL are
constituents of cell membranes, lipoproteins and lipid droplets (LD), and are now considered
as bioactive molecules. Indeed, growing evidence suggests that SL, characterized by
diverse families and species, could represent one of the main regulators of lipid metabolism …