Sphingolipids and lipoproteins in health and metabolic disorders

J Iqbal, MT Walsh, SM Hammad, MM Hussain - Trends in Endocrinology & …, 2017 - cell.com
Trends in Endocrinology & Metabolism, 2017cell.com
Sphingolipids are structurally and functionally diverse molecules with significant physiologic
functions and are found associated with cellular membranes and plasma lipoproteins. The
cellular and plasma concentrations of sphingolipids are altered in several metabolic
disorders and may serve as prognostic and diagnostic markers. Here we discuss various
sphingolipid transport mechanisms and highlight how changes in cellular and plasma
sphingolipid levels contribute to cardiovascular disease, obesity, diabetes, insulin …
Sphingolipids are structurally and functionally diverse molecules with significant physiologic functions and are found associated with cellular membranes and plasma lipoproteins. The cellular and plasma concentrations of sphingolipids are altered in several metabolic disorders and may serve as prognostic and diagnostic markers. Here we discuss various sphingolipid transport mechanisms and highlight how changes in cellular and plasma sphingolipid levels contribute to cardiovascular disease, obesity, diabetes, insulin resistance, and nonalcoholic fatty liver disease (NAFLD). Understanding of the mechanisms involved in intracellular transport, secretion, and extracellular transport may provide novel information that might be amenable to therapeutic targeting for the treatment of various metabolic disorders.
cell.com