Evidence for a novel gene associated with low tumor metastatic potential
PS Steeg, G Bevilacqua, L Kopper… - JNCI: Journal of the …, 1988 - academic.oup.com
PS Steeg, G Bevilacqua, L Kopper, UP Thorgeirsson, JE Talmadge, LA Liotta, ME Sobel
JNCI: Journal of the National Cancer Institute, 1988•academic.oup.comWe describe a gene, NM23, that is associated with the tumor metastatic process. NM23 RNA
levels were highest in cells and tumors of relatively low metastatic potential in two
experimental systems:(1) murine K-1735 melanoma cell lines, in which the gene was
identifiede, and (2) N-nitroso-N-methylurea-induced rat mammary earcinomas. NM23 RNA
levels did not correlate with cell sensitivity to host immunological responses and may,
therefore, be associated with intrinsle aggressiveness. The predicted carboxy-terminal …
levels were highest in cells and tumors of relatively low metastatic potential in two
experimental systems:(1) murine K-1735 melanoma cell lines, in which the gene was
identifiede, and (2) N-nitroso-N-methylurea-induced rat mammary earcinomas. NM23 RNA
levels did not correlate with cell sensitivity to host immunological responses and may,
therefore, be associated with intrinsle aggressiveness. The predicted carboxy-terminal …
Abstract
We describe a gene, NM23, that is associated with the tumor metastatic process. NM23 RNA levels were highest in cells and tumors of relatively low metastatic potential in two experimental systems: (1) murine K-1735 melanoma cell lines, in which the gene was identifiede, and (2) N-nitroso-N-methylurea-induced rat mammary earcinomas. NM23 RNA levels did not correlate with cell sensitivity to host immunological responses and may, therefore, be associated with intrinsle aggressiveness. The predicted carboxy-terminal protein seaquence encoded by the pNM23 cDNA clone is nove compared with Genebank animal, bacterial, and viral sequences.[J Natl Cancer Inst 1988;80:200–204]
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