Retention of uremic metabolites is a proposed cause of cognitive impairment in patients with
ESRD. We used metabolic profiling to identify and validate uremic metabolites associated
with impairment in executive function in two cohorts of patients receiving maintenance
dialysis. We performed metabolic profiling using liquid chromatography/mass spectrometry
applied to predialysis plasma samples from a discovery cohort of 141 patients and an
independent replication cohort of 180 patients participating in a trial of frequent …