[HTML][HTML] Interacting Network of the Gap Junction (GJ) Protein Connexin43 (Cx43) is Modulated by Ischemia and Reperfusion in the Heart*[S]
The coordinated and synchronized cardiac muscle contraction relies on an efficient gap
junction-mediated intercellular communication (GJIC) between cardiomyocytes, which
involves the rapid anisotropic impulse propagation through connexin (Cx)-containing
channels, namely of Cx43, the most abundant Cx in the heart. Expectedly, disturbing
mechanisms that affect channel activity, localization and turnover of Cx43 have been
implicated in several cardiomyopathies, such as myocardial ischemia. Besides gap junction …
junction-mediated intercellular communication (GJIC) between cardiomyocytes, which
involves the rapid anisotropic impulse propagation through connexin (Cx)-containing
channels, namely of Cx43, the most abundant Cx in the heart. Expectedly, disturbing
mechanisms that affect channel activity, localization and turnover of Cx43 have been
implicated in several cardiomyopathies, such as myocardial ischemia. Besides gap junction …