[PDF][PDF] An electrifying iPSC disease model: long QT syndrome type 2 and heart cells in a dish

TJ Kamp - Cell Stem Cell, 2011 - cell.com
TJ Kamp
Cell Stem Cell, 2011cell.com
In a recent Nature paper, Itzhaki et al.(2011) generate induced pluripotent stem cells (iPSCs)
from patients with a potentially fatal inherited arrhythmia, long QT syndrome type 2.
Cardiomyocytes differentiated from the patient-derived iPSCs exhibit the hallmark cardiac
electrical signatures of the disease, which can be reversed by pharmacological intervention.
In a recent Nature paper, Itzhaki et al. (2011) generate induced pluripotent stem cells (iPSCs) from patients with a potentially fatal inherited arrhythmia, long QT syndrome type 2. Cardiomyocytes differentiated from the patient-derived iPSCs exhibit the hallmark cardiac electrical signatures of the disease, which can be reversed by pharmacological intervention.
cell.com