[HTML][HTML] Tissue damage from neutrophil-induced oxidative stress in COVID-19
Nature Reviews Immunology, 2020•nature.com
The high neutrophil to lymphocyte ratio observed in critically ill patients with COVID-19 is
associated with excessive levels of reactive oxygen species (ROS), which promote a
cascade of biological events that drive pathological host responses. ROS induce tissue
damage, thrombosis and red blood cell dysfunction, which contribute to COVID-19 disease
severity. We suggest that free radical scavengers could be beneficial for the most vulnerable
patients.
associated with excessive levels of reactive oxygen species (ROS), which promote a
cascade of biological events that drive pathological host responses. ROS induce tissue
damage, thrombosis and red blood cell dysfunction, which contribute to COVID-19 disease
severity. We suggest that free radical scavengers could be beneficial for the most vulnerable
patients.
The high neutrophil to lymphocyte ratio observed in critically ill patients with COVID-19 is associated with excessive levels of reactive oxygen species (ROS), which promote a cascade of biological events that drive pathological host responses. ROS induce tissue damage, thrombosis and red blood cell dysfunction, which contribute to COVID-19 disease severity. We suggest that free radical scavengers could be beneficial for the most vulnerable patients.
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