2-Oxoglutarate-dependent oxygenases
MS Islam, TM Leissing, R Chowdhury… - Annual review of …, 2018 - annualreviews.org
2-Oxoglutarate (2OG)-dependent oxygenases (2OGXs) catalyze a remarkably diverse range
of oxidative reactions. In animals, these comprise hydroxylations and N-demethylations
proceeding via hydroxylation; in plants and microbes, they catalyze a wider range including
ring formations, rearrangements, desaturations, and halogenations. The catalytic flexibility of
2OGXs is reflected in their biological functions. After pioneering work identified the roles of
2OGXs in collagen biosynthesis, research revealed they also function in plant and animal …
of oxidative reactions. In animals, these comprise hydroxylations and N-demethylations
proceeding via hydroxylation; in plants and microbes, they catalyze a wider range including
ring formations, rearrangements, desaturations, and halogenations. The catalytic flexibility of
2OGXs is reflected in their biological functions. After pioneering work identified the roles of
2OGXs in collagen biosynthesis, research revealed they also function in plant and animal …
