[HTML][HTML] Transcriptional Regulation of the Gene Encoding the Human C-type Lectin Leukocyte Receptor AIM/CD69 and Functional Characterization of Its Tumor …
M López-Cabrera, E Muñoz, MV Blázquez… - Journal of Biological …, 1995 - ASBMB
The human activation antigen CD69 is a member of the C-type animal lectin superfamily that
functions as a signal-transmitting receptor. Although the expression of CD69 can be induced
in vitro on cells of most hematopoietic lineages with a wide variety of stimuli, in vivo it is
mainly expressed by T-lymphocytes located in the inflammatory infiltrates of several human
diseases. To elucidate the mechanisms that regulate the constitutive and inducible
expression of CD69 by leukocytes, we isolated the promoter region of the CD69 gene and …
functions as a signal-transmitting receptor. Although the expression of CD69 can be induced
in vitro on cells of most hematopoietic lineages with a wide variety of stimuli, in vivo it is
mainly expressed by T-lymphocytes located in the inflammatory infiltrates of several human
diseases. To elucidate the mechanisms that regulate the constitutive and inducible
expression of CD69 by leukocytes, we isolated the promoter region of the CD69 gene and …