Interference with Gsα-coupled receptor signaling in renin-producing cells leads to renal endothelial damage
P Lachmann, L Hickmann, A Steglich… - Journal of the …, 2017 - journals.lww.com
Intracellular cAMP, the production of which is catalyzed by the α-subunit of the stimulatory G
protein (Gsα), controls renin synthesis and release by juxtaglomerular (JG) cells of the
kidney, but may also have relevance for the physiologic integrity of the kidney. To investigate
this possibility, we generated mice with inducible knockout of Gsα in JG cells and monitored
them for 6 months after induction at 6 weeks of age. The knockout mapped exclusively to the
JG cells of the Gsα-deficient animals. Progressive albuminuria occurred in Gsα-deficient …
protein (Gsα), controls renin synthesis and release by juxtaglomerular (JG) cells of the
kidney, but may also have relevance for the physiologic integrity of the kidney. To investigate
this possibility, we generated mice with inducible knockout of Gsα in JG cells and monitored
them for 6 months after induction at 6 weeks of age. The knockout mapped exclusively to the
JG cells of the Gsα-deficient animals. Progressive albuminuria occurred in Gsα-deficient …