[HTML][HTML] TNF receptors differentially signal and are differentially expressed and regulated in the human heart
RS Al-Lamki, AP Brookes, J Wang, MJ Reid… - American Journal of …, 2009 - Elsevier
Tumor necrosis factor (TNF) utilizes two receptors, TNFR1 and 2, to initiate target cell
responses. We assessed expression of TNF, TNFRs and downstream kinases in cardiac
allografts, and compared TNF responses in heart organ cultures from wildtype (WT
C57BL/6), TNFR1-knockout (KO), TNFR2 KO, TNFR1/2 KO mice. In nonrejecting human
heart TNFR1 was strongly expressed coincidentally with inactive apoptosis signal-regulating
kinase-1 (ASK1) in cardiomyocytes (CM) and vascular endothelial cells (VEC). TNFR2 was …
responses. We assessed expression of TNF, TNFRs and downstream kinases in cardiac
allografts, and compared TNF responses in heart organ cultures from wildtype (WT
C57BL/6), TNFR1-knockout (KO), TNFR2 KO, TNFR1/2 KO mice. In nonrejecting human
heart TNFR1 was strongly expressed coincidentally with inactive apoptosis signal-regulating
kinase-1 (ASK1) in cardiomyocytes (CM) and vascular endothelial cells (VEC). TNFR2 was …