Tumor necrosis factor α (TNF-α) receptor-I is required for TNF-α-mediated fulminant virus hepatitis caused by murine hepatitis virus strain-3 infection
H Xu, H Li, D Cao, Y Wu, Y Chen - Immunology letters, 2014 - Elsevier
TNF-α plays an essential role in the pathogenesis of fulminant virus hepatitis (FH) caused by
infection with murine hepatitis virus strain-3 (MHV-3). However, the specific TNF-α receptors
(TNFR) involved in this disease and how they mediate this effect are uncertain. Here, we
showed that the expression of TNFR1 and TNFR2 in the liver and spleen was triggered by
MHV-3. However, only TNFR1−/− mice were resistant to MHV-3 mediated FH, as displayed
by a dramatic decrease in tissue necrosis and cell apoptosis in the infected spleens and …
infection with murine hepatitis virus strain-3 (MHV-3). However, the specific TNF-α receptors
(TNFR) involved in this disease and how they mediate this effect are uncertain. Here, we
showed that the expression of TNFR1 and TNFR2 in the liver and spleen was triggered by
MHV-3. However, only TNFR1−/− mice were resistant to MHV-3 mediated FH, as displayed
by a dramatic decrease in tissue necrosis and cell apoptosis in the infected spleens and …