[CITATION][C] Electron microscopy of the epiphyseal apparatus

BL Scott, DC Pease - The Anatomical record, 1956 - Wiley Online Library
BL Scott, DC Pease
The Anatomical record, 1956Wiley Online Library
Of the many facets of bone biology, the question of how the shafts of long bones increase in
length has, perhaps, stimulated most intense and prolonged scientific interest. Experimental
study on the subject began more than two centuries ago when Hales (1727) observed that
holes drilled in the shaft of growing bone always remained the same distance apart. This led
him to conclude that the growth of long bones occurred at their ends. Subsequent
investigations with fixed markers established the epiphyseal plate as the precise site of …
Of the many facets of bone biology, the question of how the shafts of long bones increase in length has, perhaps, stimulated most intense and prolonged scientific interest. Experimental study on the subject began more than two centuries ago when Hales (1727) observed that holes drilled in the shaft of growing bone always remained the same distance apart. This led him to conclude that the growth of long bones occurred at their ends. Subsequent investigations with fixed markers established the epiphyseal plate as the precise site of growth (du Hamel, 1745; Hunter, 1772). With the introduction of light microscopy came many investigations on the morphology of cartilage and bone. One of the most comprehensive studies is that of Fell ('25) on chondrogenesis and osteogenesis in the chick. Her view of endochondral bone formation, in its major aspects, has been confirmed by numerous investigators and ex-tended technically by such diversified approaches as microradioautography, histoehelmistry, biochemistry, x-ray absorption and diffraction data.
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