The role of α9β1 integrin and its ligands in the development of autoimmune diseases
S Kon, T Uede - Journal of Cell Communication and Signaling, 2018 - Springer
S Kon, T Uede
Journal of Cell Communication and Signaling, 2018•SpringerAdhesion of cells to extracellular matrix proteins through integrins expressed on the cell
surface is important for cell adhesion/motility, survival, and differentiation. Recently, α9β1
integrin was reported to be important for the development of autoimmune diseases including
rheumatoid arthritis, multiple sclerosis, and their murine models. In addition, ligands for α9β1
integrin, such as osteopontin and tenascin-C, are well established as key regulators of
autoimmune diseases. Therefore, this review focused on the role of interactions between …
surface is important for cell adhesion/motility, survival, and differentiation. Recently, α9β1
integrin was reported to be important for the development of autoimmune diseases including
rheumatoid arthritis, multiple sclerosis, and their murine models. In addition, ligands for α9β1
integrin, such as osteopontin and tenascin-C, are well established as key regulators of
autoimmune diseases. Therefore, this review focused on the role of interactions between …
Abstract
Adhesion of cells to extracellular matrix proteins through integrins expressed on the cell surface is important for cell adhesion/motility, survival, and differentiation. Recently, α9β1 integrin was reported to be important for the development of autoimmune diseases including rheumatoid arthritis, multiple sclerosis, and their murine models. In addition, ligands for α9β1 integrin, such as osteopontin and tenascin-C, are well established as key regulators of autoimmune diseases. Therefore, this review focused on the role of interactions between α9β1 integrin and its ligands in the development of autoimmune diseases.
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