[HTML][HTML] Distinct early folding and aggregation properties of Alzheimer amyloid-β peptides Aβ40 and Aβ42: stable trimer or tetramer formation by Aβ42
The amyloid β peptide (Aβ), composed of 40 or 42 amino acids, is a critical component in the
etiology of the neurodegenerative Alzheimer disease. Aβ is prone to aggregate and forms
amyloid fibrils progressively both in vitro and in vivo. To understand the process of
amyloidogenesis, it is pivotal to examine the initial stages of the folding process. We
examined the equilibrium folding properties, assembly states, and stabilities of the early
folding stages of Aβ40 and Aβ42 prior to fibril formation. We found that Aβ40 and Aβ42 have …
etiology of the neurodegenerative Alzheimer disease. Aβ is prone to aggregate and forms
amyloid fibrils progressively both in vitro and in vivo. To understand the process of
amyloidogenesis, it is pivotal to examine the initial stages of the folding process. We
examined the equilibrium folding properties, assembly states, and stabilities of the early
folding stages of Aβ40 and Aβ42 prior to fibril formation. We found that Aβ40 and Aβ42 have …