Intracarotid infusion of the nitric oxide synthase inhibitor, L-NMMA, modestly decreases cerebral blood flow in human subjects
S Joshi, WL Young, DH Duong… - The Journal of the …, 2000 - pubs.asahq.org
Background The authors hypothesized that if nitric oxide (NO) was a determinant of
background cerebrovascular tone, intracarotid infusion of NG-monomethyl-L-arginine (L-
NMMA), a NO synthase (NOS) inhibitor, would decrease cerebral blood flow (CBF) and
intracarotid L-arginine would reverse its effect. Methods In angiographically normal cerebral
hemispheres, after the initial dose-escalation studies (protocol 1), the authors determined
the effect of intracarotid L-NMMA (50 mg/min for 5 min) on CBF and mean arterial pressure …
background cerebrovascular tone, intracarotid infusion of NG-monomethyl-L-arginine (L-
NMMA), a NO synthase (NOS) inhibitor, would decrease cerebral blood flow (CBF) and
intracarotid L-arginine would reverse its effect. Methods In angiographically normal cerebral
hemispheres, after the initial dose-escalation studies (protocol 1), the authors determined
the effect of intracarotid L-NMMA (50 mg/min for 5 min) on CBF and mean arterial pressure …