[HTML][HTML] Nuclear factor of activated T cells and serum response factor cooperatively regulate the activity of an α-actin intronic enhancer
LVG Bosc, JJ Layne, MT Nelson… - Journal of Biological …, 2005 - ASBMB
Expression of α-actin in smooth muscle cells (SMCs) is regulated, in part, by an intronic
serum response factor (SRF)-binding CArG element. We have identified a conserved
nuclear factor of activated T cells (NFAT) binding site that overlaps this CArG box and tested
the hypothesis that this site plays a previously unrecognized role in regulating α-actin
expression. A reporter construct prepared using a 56-bp region of the mouse α-actin first
intron containing SRF, NFAT, and AP-1 sites (SNAP) acted as an enhancer element in the …
serum response factor (SRF)-binding CArG element. We have identified a conserved
nuclear factor of activated T cells (NFAT) binding site that overlaps this CArG box and tested
the hypothesis that this site plays a previously unrecognized role in regulating α-actin
expression. A reporter construct prepared using a 56-bp region of the mouse α-actin first
intron containing SRF, NFAT, and AP-1 sites (SNAP) acted as an enhancer element in the …
