TRPV1 channels facilitate glutamate transmission in the striatum
A Musella, V De Chiara, S Rossi, C Prosperetti… - Molecular and Cellular …, 2009 - Elsevier
Transient receptor potential vanilloid 1 (TRPV1) channels participate in the modulation of
synaptic transmission in the periphery and in central structures. Here, we investigated the
role of TRPV1 channels in the control of both excitatory and inhibitory transmission in the
striatum. Pharmacological stimulation of TRPV1 channels with capsaicin (10 nM) selectively
enhanced the frequency of glutamate-mediated spontaneous (sEPSCs) and miniature
excitatory postsynaptic currents (mEPSCs) recorded from putative striatal medium spiny …
synaptic transmission in the periphery and in central structures. Here, we investigated the
role of TRPV1 channels in the control of both excitatory and inhibitory transmission in the
striatum. Pharmacological stimulation of TRPV1 channels with capsaicin (10 nM) selectively
enhanced the frequency of glutamate-mediated spontaneous (sEPSCs) and miniature
excitatory postsynaptic currents (mEPSCs) recorded from putative striatal medium spiny …