Neuronal traffic signals in tardive dyskinesia: not enough “stop” in the motor striatum

SM Stahl - CNS spectrums, 2017 - cambridge.org
SM Stahl
CNS spectrums, 2017cambridge.org
Neuronal traffic signals in tardive dyskinesia: not enough “stop” in the motor striatum Page 1
Neuronal traffic signals in tardive dyskinesia: not enough “stop” in the motor striatum Stephen
M. Stahl ISSUE: Tardive dyskinesia is a disturbance in the balance between dopamine
receptor stimulation and dopamine receptor blockade in the motor striatum, with hypothetically
too much stimulation of supersensitive D2 receptors, resulting in “don’t stop” signaling to
motor output. Take-Home Points ’ The so-called “direct” pathway of the extrapyramidal system …
Tardive dyskinesia is a disturbance in the balance between dopamine receptor stimulation and dopamine receptor blockade in the motor striatum, with hypothetically too much stimulation of supersensitive D2 receptors, resulting in “don’t stop” signaling to motor output.
Cambridge University Press