[HTML][HTML] A metabolic throttle regulates the epigenetic state of rDNA
I Grummt, AG Ladurner - Cell, 2008 - cell.com
I Grummt, AG Ladurner
Cell, 2008•cell.comThe synthesis of ribosomal RNA (rRNA) is carefully tuned to match nutritional conditions. In
this issue, Murayama et al.(2008) describe a mechanism that couples the energy status of
the cell to heterochromatin formation and silencing of rRNA genes. They show that an
altered NAD+/NADH ratio in response to glucose starvation regulates the silencing activity of
eNoSC, a complex consisting of the NAD+-dependent histone deacetylase SIRT1, the
histone methyltransferase SUV39H1, and a new protein called nucleomethylin (NML) …
this issue, Murayama et al.(2008) describe a mechanism that couples the energy status of
the cell to heterochromatin formation and silencing of rRNA genes. They show that an
altered NAD+/NADH ratio in response to glucose starvation regulates the silencing activity of
eNoSC, a complex consisting of the NAD+-dependent histone deacetylase SIRT1, the
histone methyltransferase SUV39H1, and a new protein called nucleomethylin (NML) …
The synthesis of ribosomal RNA (rRNA) is carefully tuned to match nutritional conditions. In this issue, Murayama et al. (2008) describe a mechanism that couples the energy status of the cell to heterochromatin formation and silencing of rRNA genes. They show that an altered NAD+/NADH ratio in response to glucose starvation regulates the silencing activity of eNoSC, a complex consisting of the NAD+-dependent histone deacetylase SIRT1, the histone methyltransferase SUV39H1, and a new protein called nucleomethylin (NML). These results suggest a mechanism that links cell physiology to rDNA silencing, which in turn is a prerequisite for nucleolar integrity and cell survival.
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