[HTML][HTML] HOMA1-IR and HOMA2-IR indexes in identifying insulin resistance and metabolic syndrome: Brazilian Metabolic Syndrome Study (BRAMS)
B Geloneze, ACJ Vasques, CFC Stabe… - … de Endocrinologia & …, 2009 - SciELO Brasil
Arquivos Brasileiros de Endocrinologia & Metabologia, 2009•SciELO Brasil
OBJECTIVE: To investigate cut-off values for HOMA1-IR and HOMA2-IR to identify insulin
resistance (IR) and metabolic syndrome (MS), and to assess the association of the indexes
with components of the MS. METHODS: Nondiabetic subjects from the Brazilian Metabolic
Syndrome Study were studied (n= 1,203, 18 to 78 years). The cut-off values for IR were
determined from the 90th percentile in the healthy group (n= 297) and, for MS, a ROC curve
was generated for the total sample. RESULTS: In the healthy group, HOMA-IR indexes were …
resistance (IR) and metabolic syndrome (MS), and to assess the association of the indexes
with components of the MS. METHODS: Nondiabetic subjects from the Brazilian Metabolic
Syndrome Study were studied (n= 1,203, 18 to 78 years). The cut-off values for IR were
determined from the 90th percentile in the healthy group (n= 297) and, for MS, a ROC curve
was generated for the total sample. RESULTS: In the healthy group, HOMA-IR indexes were …
OBJECTIVE
To investigate cut-off values for HOMA1-IR and HOMA2-IR to identify insulin resistance (IR) and metabolic syndrome (MS), and to assess the association of the indexes with components of the MS.
METHODS
Nondiabetic subjects from the Brazilian Metabolic Syndrome Study were studied (n = 1,203, 18 to 78 years). The cut-off values for IR were determined from the 90th percentile in the healthy group (n = 297) and, for MS, a ROC curve was generated for the total sample.
RESULTS
In the healthy group, HOMA-IR indexes were associated with central obesity, triglycerides and total cholesterol (p < 0.001). The cut-off values for IR were: HOMA1-IR > 2.7 and HOMA2-IR > 1.8; and, for MS were: HOMA1-IR > 2.3 (sensitivity: 76.8%; specificity: 66.7%) and HOMA2-IR > 1.4 (sensitivity: 79.2%; specificity: 61.2%).
CONCLUSION
The cut-off values identified for HOMA1-IR and HOMA2-IR indexes have a clinical and epidemiological application for identifying IR and MS in Westernized admixtured multi-ethnic populations.
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