Respiratory chemoreflexes and effects of cortical activation state in urethane anesthetized rats
JA Boon, NBL Garnett, JM Bentley… - Respiratory physiology & …, 2004 - Elsevier
Urethane anesthetized (< 1.3 g/kg), Sprague–Dawley (SD) rats spontaneously cycled
between a cortically desynchronized state (State I) and a cortically synchronized state (State
III), which were very similar to awake and slow wave sleep (SWS) states in unanesthetized
animals, based on EEG criteria. These low levels of urethane anaesthesia did not cause
significant respiratory depression or reductions in sensitivity to hypoxia (10% O2 in nitrogen)
or hypercapnia (5% CO2 in air) in rats in either State I or State III. Thus, breathing frequency …
between a cortically desynchronized state (State I) and a cortically synchronized state (State
III), which were very similar to awake and slow wave sleep (SWS) states in unanesthetized
animals, based on EEG criteria. These low levels of urethane anaesthesia did not cause
significant respiratory depression or reductions in sensitivity to hypoxia (10% O2 in nitrogen)
or hypercapnia (5% CO2 in air) in rats in either State I or State III. Thus, breathing frequency …