The proliferation center microenvironment and prognostic markers in chronic lymphocytic leukemia/small lymphocytic lymphoma
LA Soma, FE Craig, SH Swerdlow - Human pathology, 2006 - Elsevier
Prognostication in chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL)
based, in part, on ZAP-70 and CD38 expression, and to a lesser extent, on MUM1/IRF4
expression, is currently of great interest. The more aggressive type of CLL/SLL is reportedly
characterized by neoplastic cells that are more responsive to B-cell signaling with
proliferation centers (PCs), a potentially important site of neoplastic cell stimulation. To study
the relationship of these markers to each other and to the pattern of PCs …
based, in part, on ZAP-70 and CD38 expression, and to a lesser extent, on MUM1/IRF4
expression, is currently of great interest. The more aggressive type of CLL/SLL is reportedly
characterized by neoplastic cells that are more responsive to B-cell signaling with
proliferation centers (PCs), a potentially important site of neoplastic cell stimulation. To study
the relationship of these markers to each other and to the pattern of PCs …