The IL-23/Th17 axis contributes to renal injury in experimental glomerulonephritis
HJ Paust, JE Turner, OM Steinmetz… - Journal of the …, 2009 - journals.lww.com
T cells infiltrate the kidney in both human and experimental glomerulonephritis, and several
lines of evidence indicate that T cell-mediated tissue damage plays an important role in the
immunopathogenesis of renal inflammatory diseases. However, the functions of the different
T cell subsets, particularly the recently identified interleukin-17 (IL-17)-producing T cells
(Th17 cells), are incompletely understood in glomerulonephritis. Here, we identified renal IL-
17-producing T cells in the T cell-mediated model of nephrotoxic nephritis in mice. In vitro, IL …
lines of evidence indicate that T cell-mediated tissue damage plays an important role in the
immunopathogenesis of renal inflammatory diseases. However, the functions of the different
T cell subsets, particularly the recently identified interleukin-17 (IL-17)-producing T cells
(Th17 cells), are incompletely understood in glomerulonephritis. Here, we identified renal IL-
17-producing T cells in the T cell-mediated model of nephrotoxic nephritis in mice. In vitro, IL …