Monoclonal antibodies to human complement receptor (CR1) detect defects in glomerular diseases

SN Emancipator, K Iida, V Nussenzweig… - Clinical immunology and …, 1983 - Elsevier
The complement receptor for C3b of the epithelial cells of human glomeruli is structurally
and functionally very similar or identical to CR1, the complement receptor for C3b and C4b
present on the membrane of red cells and leukocytes. Four monoclonal antibodies directed
against separate epitopes of CR1 react with an antigen in the glomeruli, which appears to
be present on the epithelial podocytes. Moreover, the monoclonal antibodies very effectively
inhibit the binding of C3b-bearing red cells to the glomeruli. The pattern of …