Brg-1 is required for maximal transcription of the human matrix metalloproteinase-2 gene
Z Ma, MJ Chang, R Shah, J Adamski, X Zhao… - Journal of Biological …, 2004 - jbc.org
Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases whose aberrant
expression are correlated with tumor invasion and angiogenesis. The transcription factors
Sp1, Sp3, and AP-2 are required for constitutive expression of MMP-2 in tumor cells;
however, the regulatory mechanisms of MMP-2 expression are not well understood. We
investigated the involvement of Brg-1, the ATPase subunit of the SWI/SNF complex, in
human MMP-2 gene transcription. Reconstitution of Brg-1 enhances MMP-2 transcription in …
expression are correlated with tumor invasion and angiogenesis. The transcription factors
Sp1, Sp3, and AP-2 are required for constitutive expression of MMP-2 in tumor cells;
however, the regulatory mechanisms of MMP-2 expression are not well understood. We
investigated the involvement of Brg-1, the ATPase subunit of the SWI/SNF complex, in
human MMP-2 gene transcription. Reconstitution of Brg-1 enhances MMP-2 transcription in …