[HTML][HTML] BRG1 chromatin remodeling activity is required for efficient chromatin binding by repressor element 1-silencing transcription factor (REST) and facilitates …
Chromatin remodeling enzymes such as SWI/SNF use the hydrolysis of ATP to power the
movement of nucleosomes with respect to DNA. BRG1, one of the ATPases of the SWI/SNF
complex, can be recruited by both activators and repressors, although the precise role of
BRG1 in mechanisms of repression has thus far remained unclear. One transcription factor
that recruits BRG1 as a corepressor is the repressor element 1-silencing transcription factor
(REST). Here we address for the first time the mechanism of BRG1 activity in gene …
movement of nucleosomes with respect to DNA. BRG1, one of the ATPases of the SWI/SNF
complex, can be recruited by both activators and repressors, although the precise role of
BRG1 in mechanisms of repression has thus far remained unclear. One transcription factor
that recruits BRG1 as a corepressor is the repressor element 1-silencing transcription factor
(REST). Here we address for the first time the mechanism of BRG1 activity in gene …