MicroRNA-19b/221/222 induces endothelial cell dysfunction via suppression of PGC-1α in the progression of atherosclerosis
Background Peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) is a
master regulator of cellular energy metabolism that is associated with many cardiovascular
diseases, including atherosclerosis. However, the role and underling regulatory
mechanisms of PGC-1α in the pathogenesis of atherosclerosis are not completely
understood. Here, we identified the microRNAs that post-transcriptionally regulate PGC-1α
production and their roles in the pathogenesis of atherosclerosis. Methods and results A …
master regulator of cellular energy metabolism that is associated with many cardiovascular
diseases, including atherosclerosis. However, the role and underling regulatory
mechanisms of PGC-1α in the pathogenesis of atherosclerosis are not completely
understood. Here, we identified the microRNAs that post-transcriptionally regulate PGC-1α
production and their roles in the pathogenesis of atherosclerosis. Methods and results A …
