Tryptophan catabolism and T-cell tolerance: immunosuppression by starvation?
AL Mellor, DH Munn - Immunology today, 1999 - cell.com
AL Mellor, DH Munn
Immunology today, 1999•cell.comSome macrophages inhibit microbial infections by producing indoleamine 2, 3 dioxygenase
(IDO), which catabolizes tryptophan. Here, Andrew Mellor and David Munn discuss
evidence that cells that synthesize IDO protect the mammalian fetus from maternal T-cell
attack and argue that this mechanism might have wider implications for the control of T-cell
responses.
(IDO), which catabolizes tryptophan. Here, Andrew Mellor and David Munn discuss
evidence that cells that synthesize IDO protect the mammalian fetus from maternal T-cell
attack and argue that this mechanism might have wider implications for the control of T-cell
responses.
Abstract
Some macrophages inhibit microbial infections by producing indoleamine 2,3 dioxygenase (IDO), which catabolizes tryptophan. Here, Andrew Mellor and David Munn discuss evidence that cells that synthesize IDO protect the mammalian fetus from maternal T-cell attack and argue that this mechanism might have wider implications for the control of T-cell responses.
cell.com