In connection with the increasing interest in metabolic regulation of the immune response,
this review discusses current advances in understanding the role of leucine and leucine
metabolism in T lymphocyte (T cell) activation. T cell activation during the development of an
immune response depends on metabolic reprogramming to ensure that sufficient nutrients
and energy are taken up by the highly proliferating T cells. Leucine has been described as
an important essential amino acid and a nutrient signal that activates complex 1 of the …