[HTML][HTML] Asparagine synthetase: Function, structure, and role in disease
CL Lomelino, JT Andring, R McKenna… - Journal of Biological …, 2017 - ASBMB
Asparagine synthetase (ASNS) converts aspartate and glutamine to asparagine and
glutamate in an ATP-dependent reaction. ASNS is present in most, if not all, mammalian
organs, but varies widely in basal expression. Human ASNS activity is highly responsive to
cellular stress, primarily by increased transcription from a single gene located on
chromosome 7. Elevated ASNS protein expression is associated with resistance to
asparaginase therapy in childhood acute lymphoblastic leukemia. There is evidence that …
glutamate in an ATP-dependent reaction. ASNS is present in most, if not all, mammalian
organs, but varies widely in basal expression. Human ASNS activity is highly responsive to
cellular stress, primarily by increased transcription from a single gene located on
chromosome 7. Elevated ASNS protein expression is associated with resistance to
asparaginase therapy in childhood acute lymphoblastic leukemia. There is evidence that …