α-Methylacyl coenzyme A racemase as a tissue biomarker for prostate cancer

MA Rubin, M Zhou, SM Dhanasekaran, S Varambally… - Jama, 2002 - jamanetwork.com
ContextMolecular profiling of prostate cancer has led to the identification of candidate
biomarkers and regulatory genes. Discoveries from these genome-scale approaches may
have applicability in the analysis of diagnostic prostate specimens. ObjectivesTo determine
the expression and clinical utility of α-methylacyl coenzyme A racemase (AMACR), a gene
identified as being overexpressed in prostate cancer by global profiling strategies.
DesignFour gene expression data sets from independent DNA microarray analyses were …