Redefining definitive endoderm subtypes by robust induction of human induced pluripotent stem cells
K Matsuno, SI Mae, C Okada, M Nakamura… - Differentiation, 2016 - Elsevier
Many reports have described methods that induce definitive endoderm (DE) cells from
human pluripotent stem cells (hPSCs). However, it is unclear whether the differentiation
propensity of these DE cells is uniform. This uncertainty is due to the different developmental
stages that give rise to anterior and posterior DE from anterior primitive streak (APS).
Therefore, these DE cell populations might be generated from the different stages of APS
cells, which affect the DE cell differentiation potential. Here, we succeeded in selectively …
human pluripotent stem cells (hPSCs). However, it is unclear whether the differentiation
propensity of these DE cells is uniform. This uncertainty is due to the different developmental
stages that give rise to anterior and posterior DE from anterior primitive streak (APS).
Therefore, these DE cell populations might be generated from the different stages of APS
cells, which affect the DE cell differentiation potential. Here, we succeeded in selectively …