Loss of CDX2/CK20 expression is associated with poorly differentiated carcinoma, the CpG island methylator phenotype, and adverse prognosis in microsatellite …
JH Kim, YY Rhee, JM Bae, NY Cho… - The American Journal of …, 2013 - journals.lww.com
Several previous studies have demonstrated that the CDX2-negative (CDX2−) and/or CK20-
negative (CK20−) phenotypes of colorectal cancers (CRCs) might be associated with high
levels of microsatellite instability (MSI-H). The aim of this study was to investigate the
clinicopathologic and molecular features of MSI-H CRCs with different CDX2/CK20
expression statuses. The CDX2 and CK20 expression statuses were
immunohistochemically evaluated in 109 MSI-H CRC tissue samples, and the correlations of …
negative (CK20−) phenotypes of colorectal cancers (CRCs) might be associated with high
levels of microsatellite instability (MSI-H). The aim of this study was to investigate the
clinicopathologic and molecular features of MSI-H CRCs with different CDX2/CK20
expression statuses. The CDX2 and CK20 expression statuses were
immunohistochemically evaluated in 109 MSI-H CRC tissue samples, and the correlations of …