[HTML][HTML] CDX2 as a prognostic biomarker in colon cancer

P Dalerba, D Sahoo, MF Clarke - The New England journal of …, 2016 - ncbi.nlm.nih.gov
P Dalerba, D Sahoo, MF Clarke
The New England journal of medicine, 2016ncbi.nlm.nih.gov
Coebergh van den Braak et al. report that they found no association between CDX2 mRNA
expression and prognosis in two cohorts of patients with stage II colon cancer. In their own
cohort of 144 patients, tumors were analyzed by means of RNA sequencing (unpublished
data). In the cohort of 90 patients from the Academic Medical Center in Amsterdam, tumors
were analyzed by means of gene-expression arrays and the results were deposited in the
National Center for Biotechnology Information Gene Expression Omnibus under accession …
Coebergh van den Braak et al. report that they found no association between CDX2 mRNA expression and prognosis in two cohorts of patients with stage II colon cancer. In their own cohort of 144 patients, tumors were analyzed by means of RNA sequencing (unpublished data). In the cohort of 90 patients from the Academic Medical Center in Amsterdam, tumors were analyzed by means of gene-expression arrays and the results were deposited in the National Center for Biotechnology Information Gene Expression Omnibus under accession number GSE33113.
It is difficult for us to comment on the first cohort, since we have no access to the primary data, the methods used to collect and normalize them, and the clinical information about these patients. With regard to the second cohort, the Academic Medical Center group published their findings on the GSE33113 data set, and they reported that lack of CDX2 expression was characteristic of a tumor subgroup that is associated with a poor prognosis. 1 This finding is consistent with those of our study, and it was validated at the mRNA-expression level by means of real-time quantitative polymerase-chain-reaction assays and at the protein-expression level by means of immunohistochemical analysis. The association between a lack of CDX2 protein expression and decreased patient survival was recently observed in a study from Seoul National University that involved an independent cohort of 713 patients. 2
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