Results of surgery in symptomatic non-hydrocephalic pineal cysts: role of magnetic resonance imaging biomarkers indicative of central venous hypertension
PK Eide, G Ringstad - Acta neurochirurgica, 2017 - Springer
PK Eide, G Ringstad
Acta neurochirurgica, 2017•SpringerBackground We have previously proposed that pineal cysts (PCs) may result in crowding of
the pineal recess, causing symptoms due to compression of the internal cerebral veins and
central venous hypertension. In the present study, we compared clinical outcome of different
treatment modalities in symptomatic individuals with non-hydrocephalic PCs. Methods The
study included all patients managed surgically for non-hydrocephalic PCs in our Department
of Neurosurgery over a 10-year period. We applied a questionnaire to determine occurrence …
the pineal recess, causing symptoms due to compression of the internal cerebral veins and
central venous hypertension. In the present study, we compared clinical outcome of different
treatment modalities in symptomatic individuals with non-hydrocephalic PCs. Methods The
study included all patients managed surgically for non-hydrocephalic PCs in our Department
of Neurosurgery over a 10-year period. We applied a questionnaire to determine occurrence …
Background
We have previously proposed that pineal cysts (PCs) may result in crowding of the pineal recess, causing symptoms due to compression of the internal cerebral veins and central venous hypertension. In the present study, we compared clinical outcome of different treatment modalities in symptomatic individuals with non-hydrocephalic PCs.
Methods
The study included all patients managed surgically for non-hydrocephalic PCs in our Department of Neurosurgery over a 10-year period. We applied a questionnaire to determine occurrence of symptoms before and after surgery, which allowed the use of a grading scale for symptom severity. Magnetic resonance imaging (MRI) biomarkers indicative of central venous hypertension were assessed before and after surgery.
Results
Relief of symptoms after surgery was most efficiently obtained by complete microsurgical cyst removal [n = 15; no (0/15), some (1/15) or marked (14/15) improvement], and to a lesser extent by microsurgical cyst fenestration [n = 6; no (2/6), some (4/6) or marked (0/6) improvement]. Shunt surgery was not successful [n = 6; no (5/6), some (1/6) or marked (0/6) improvement]. In all patients, the proposed MRI biomarkers gave evidence of central venous hypertension (PC grades 2–4).
Conclusions
Microsurgical cyst removal provided marked symptom relief in symptomatic individuals with non-hydrocephalic PCs and MRI biomarkers of central venous hypertension. The hypothesis that PC-induced crowding of the pineal recess may compromise venous run-off and induce a central venous hypertension syndrome deserves further study.
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