Diet‐induced adaptation of vagal afferent function

S Kentish, H Li, LK Philp, TA O'Donnell… - The Journal of …, 2012 - Wiley Online Library
S Kentish, H Li, LK Philp, TA O'Donnell, NJ Isaacs, RL Young, GA Wittert, LA Blackshaw…
The Journal of physiology, 2012Wiley Online Library
Non‐technical summary Obesity is the result of a disruption in the maintenance of energy
balance such that energy intake exceeds expenditure. Why this occurs is unknown. We
show that after food deprivation or consumption of a high fat diet gastric vagal afferent
responses to distension are reduced. In addition, the effect of the orexigenic peptide ghrelin
is enhanced. Thus the satiety signal is reduced not only after food deprivation but also after
a high fat diet. This reduction in satiety signalling may explain the increase in energy intake …
Non‐technical summary  Obesity is the result of a disruption in the maintenance of energy balance such that energy intake exceeds expenditure. Why this occurs is unknown. We show that after food deprivation or consumption of a high fat diet gastric vagal afferent responses to distension are reduced. In addition, the effect of the orexigenic peptide ghrelin is enhanced. Thus the satiety signal is reduced not only after food deprivation but also after a high fat diet. This reduction in satiety signalling may explain the increase in energy intake and disruption in maintenance of energy balance in obesity.
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