[HTML][HTML] Adipose tissue deficiency, glucose intolerance, and increased atherosclerosis result from mutation in the mouse fatty liver dystrophy (fld) gene
K Reue, P Xu, XP Wang, BG Slavin - Journal of lipid research, 2000 - ASBMB
The fatty liver dystrophy (fld) mutant mouse is characterized by neonatal fatty liver and
hypertriglyceridemia that resolve at weaning, and neuropathy affecting peripheral nerve in
adulthood. We now report additional significant manifestations of this single gene mutation,
which include adipose tissue deficiency, glucose intolerance, and increased susceptibility to
atherosclerosis. In adult fld/fld mice, both white and brown fat pads exhibit an 80% reduction
in mass compared with wild-type controls, and consist of immature adipocytes as assessed …
hypertriglyceridemia that resolve at weaning, and neuropathy affecting peripheral nerve in
adulthood. We now report additional significant manifestations of this single gene mutation,
which include adipose tissue deficiency, glucose intolerance, and increased susceptibility to
atherosclerosis. In adult fld/fld mice, both white and brown fat pads exhibit an 80% reduction
in mass compared with wild-type controls, and consist of immature adipocytes as assessed …