[HTML][HTML] Perilipin-2 deletion promotes carbohydrate-mediated browning of white adipose tissue at ambient temperature
AE Libby, ES Bales, J Monks, DJ Orlicky… - Journal of lipid …, 2018 - ASBMB
Mice lacking perilipin-2 (Plin2-null) are resistant to obesity, insulin resistance, and fatty liver
induced by Western or high-fat diets. In the current study, we found that, compared with WT
mice on Western diet, Plin2-null adipose tissue was more insulin sensitive and inguinal
subcutaneous white adipose tissue (iWAT) exhibited profound browning and robust
induction of thermogenic and carbohydrate-responsive genetic programs at room
temperature. Surprisingly, these Plin2-null responses correlated with the content of simple …
induced by Western or high-fat diets. In the current study, we found that, compared with WT
mice on Western diet, Plin2-null adipose tissue was more insulin sensitive and inguinal
subcutaneous white adipose tissue (iWAT) exhibited profound browning and robust
induction of thermogenic and carbohydrate-responsive genetic programs at room
temperature. Surprisingly, these Plin2-null responses correlated with the content of simple …