[HTML][HTML] Increased glucose metabolism and glycerolipid formation by fatty acids and GPR40 receptor signaling underlies the fatty acid potentiation of insulin secretion
M El-Azzouny, CR Evans, MK Treutelaar… - Journal of Biological …, 2014 - ASBMB
Acute fatty acid (FA) exposure potentiates glucose-stimulated insulin secretion in β cells
through metabolic and receptor-mediated effects. We assessed the effect of fatty acids on
the dynamics of the metabolome in INS-1 cells following exposure to [U-13 C] glucose to
assess flux through metabolic pathways. Metabolite profiling showed a fatty acid-induced
increase in long chain acyl-CoAs that were rapidly esterified with glucose-derived glycerol-3-
phosphate to form lysophosphatidic acid, mono-and diacylglycerols, and other glycerolipids …
through metabolic and receptor-mediated effects. We assessed the effect of fatty acids on
the dynamics of the metabolome in INS-1 cells following exposure to [U-13 C] glucose to
assess flux through metabolic pathways. Metabolite profiling showed a fatty acid-induced
increase in long chain acyl-CoAs that were rapidly esterified with glucose-derived glycerol-3-
phosphate to form lysophosphatidic acid, mono-and diacylglycerols, and other glycerolipids …