[HTML][HTML] Metabolic fate of glucose and candidate signaling and excess-fuel detoxification pathways in pancreatic β-cells

Y Mugabo, S Zhao, J Lamontagne, A Al-Mass… - Journal of Biological …, 2017 - ASBMB
Glucose metabolism promotes insulin secretion in β-cells via metabolic coupling factors that
are incompletely defined. Moreover, chronically elevated glucose causes β-cell dysfunction,
but little is known about how cells handle excess fuels to avoid toxicity. Here we sought to
determine which among the candidate pathways and coupling factors best correlates with
glucose-stimulated insulin secretion (GSIS), define the fate of glucose in the β-cell, and
identify pathways possibly involved in excess-fuel detoxification. We exposed isolated rat …