[HTML][HTML] Chronic exposure to excess nutrients left-shifts the concentration dependence of glucose-stimulated insulin secretion in pancreatic β-cells
KA Erion, CA Berdan, NE Burritt, BE Corkey… - Journal of Biological …, 2015 - ASBMB
Hyperinsulinemia (HI) is elevated plasma insulin at basal glucose. Impaired glucose
tolerance is associated with HI, although the exact cause and effect relationship remains
poorly defined. We tested the hypothesis that HI can result from an intrinsic response of the β-
cell to chronic exposure to excess nutrients, involving a shift in the concentration
dependence of glucose-stimulated insulin secretion. INS-1 (832/13) cells were cultured in
either a physiological (4 mm) or high (11 mm) glucose concentration with or without …
tolerance is associated with HI, although the exact cause and effect relationship remains
poorly defined. We tested the hypothesis that HI can result from an intrinsic response of the β-
cell to chronic exposure to excess nutrients, involving a shift in the concentration
dependence of glucose-stimulated insulin secretion. INS-1 (832/13) cells were cultured in
either a physiological (4 mm) or high (11 mm) glucose concentration with or without …